Effects of Hippocampal Ablation on Learning in the Rat (2022)


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  • References (22)
  • Cited by (7)
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Progress in Brain Research

Volume 27,


, Pages 305-317

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Publisher Summary

This chapter presents the study that is designed to analyze the nature of the hippocampal involvement in learning. In recent years, increased attention has been paid to the neural mechanisms that play an important role in the inhibitory control of behavior. In the present series of experiments, involvement of the hippocampus in the inhibitory control of behavior is investigated. An increase in activity and the increased resistance to extinction in a runway are also observed after the hippocampal ablation. Several experiments and results of these experiments are given in the chapter to find out hippocampal ablation. All these findings suggest that the hippocampus plays an important role in the inhibitory control of behavior. Similar evidence regarding the inhibitory control has been obtained from the studies of passive avoidance. It is possible that these neural structures as well as the hippocampus form a common diffuse system which exerts an inhibitory control over the behavior.

References (22)

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  • Cited by (7)

    • The hearing hippocampus

      2022, Progress in Neurobiology

      The hippocampus has a well-established role in spatial and episodic memory but a broader function has been proposed including aspects of perception and relational processing. Neural bases of sound analysis have been described in the pathway to auditory cortex, but wider networks supporting auditory cognition are still being established. We review what is known about the role of the hippocampus in processing auditory information, and how the hippocampus itself is shaped by sound. In examining imaging, recording, and lesion studies in species from rodents to humans, we uncover a hierarchy of hippocampal responses to sound including during passive exposure, active listening, and the learning of associations between sounds and other stimuli. We describe how the hippocampus' connectivity and computational architecture allow it to track and manipulate auditory information – whether in the form of speech, music, or environmental, emotional, or phantom sounds. Functional and structural correlates of auditory experience are also identified. The extent of auditory-hippocampal interactions is consistent with the view that the hippocampus makes broad contributions to perception and cognition, beyond spatial and episodic memory. More deeply understanding these interactions may unlock applications including entraining hippocampal rhythms to support cognition, and intervening in links between hearing loss and dementia.

    • Brightness discrimination learning under conditions of cue enhancement by rats with lesions in the amygdala or hippocampus

      1977, Brain Research

      Three groups of rats, one with amygdala lesions, one with hippocampal lesions and a control group were trained on a brightness discrimination task under one of three different conditions, enhancement of the negative cue, enhancement of the positive cue or a non-enhanced condition. Animals with amygdala lesions showed retarded learning compared with normal animals and those with hippocampal lesions under the positive cue enhancement condition. Under the negative cue enhancement condition animals with hippocampal lesions were significantly handicapped compared with the other two groups. Results are discussed in relation to the Douglas and Pribram5 concept of a reciprocal linking of the amygdala and hippocampal systems in discrimination learning with the amygdala functioning as a reinforce register system and the hippocampus as an error evaluation system.

    • A persistence of responding in hyperstriatal chicks

      1976, Behavioral Biology

      Two-week-old Gallus chicks after lesion of the dorsal midline hyperstriatum accessorium are less easily distracted by novelty from the performance of a trained runway response than those with more lateral or posterior hyperstriatal damage or sham-operated controls. With dorsal midline hyperstriatal lesions, chicks also show delayed acquisition of a passive-avoidance task and an impaired response pattern on a delayed-response task compared to controls. The apparent continuation of the trained responding characteristic of chicks with these lesions when experimental contingencies change is tentatively compared with the behavior of mammals with limbic lesions.

    • Stimulus control of behavior and limbic lesions in rats

      1974, Physiology and Behavior

      Rats with hippocampal lesions or sham operations learned a tone discrimination significantly faster than rats with amygdala lesions. Relative tone generalization gradients were significantly steeper for the animals with hippocampal lesions than for the other two groups. Performance on a light discrimination by the animals with hippocampal lesions was impaired, compared to the sham animals, when the tone (former S+) was present but irrelevant. The behavior of the amygdala animals was interpreted as being due to an inability to inhibit responding. The behavior of the animals with hippocampal lesions was interpreted as being due to an inability to shift attention from one stimulus to another.

    • Discrimination learning and stimulus generalization in rats with hippocampal lesions

      1973, Physiology and Behavior

      Rats with hippocampal lesions and sham operated control animals were trained on a go-no-go tone discrimination. For half of the animals of each group the tone was the positive stimulus while for the other half the tone was negative. The hippocampal tone negative group took the greatest number of days to learn the task. Tone generalization tests administered the day after the learning criterion was reached did not yield any differences in either excitatory or inhibitory stimulus control between the hippocampal and sham animals.

    • Selective olfactory bulb lesions: Reactivity changes and avoidance learning in rats

      1972, Physiology and Behavior

      Male rats with bilateral lesions in different parts of the olfactory system behaved differently on several tasks. All lesioned animals were hyperactive in an open field test, learned active shuttle-box avoidance faster, and were more difficult to handle than sham operates. Animals with lesions confined to the olfactory bulb proper defecated more on several measures than animals with lesions extending to the olfactory tubercle, and only deeply lesioned animals failed to learn a step-down passive avoidance task. In a startle testing apparatus, all lesioned animals habituated more quickly than sham operates although the minimally lesioned animals showed greater freezing responses than other lesioned groups. Results are discussed in terms of possible alterations in limbic function leading to site-dependent changes in motor reactivity or emotionality.

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    More complete reports will be published in Jap. Psychol. Res., 7, 1965, 8, 1967.

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    Copyright © 1967 Elsevier Science Publishers B.V. Published by Elsevier B.V. All rights reserved.

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